Squamous Papilloma
What is a Squamous Papilloma?

Squamous papillomata (SP) are common warty growths found in the mouth (they account for 3 - 4% of all biopsied
oral soft tissue lesions).

SP’s of the mouth occurs at all ages of life but is usually diagnosed in persons between 30 - 50 years of age.

There is no gender predilection and any surface of the mouth may be affected (most commonly though on the
tongue, lips or cheek surfaces).

What is the Cause of a Squamous Papilloma?

Many are thought to be due to viral infection of the skin by the Human Papilloma Virus (HPV), a commonly
occurring virus that is also responsible for the
common wart (Verruca Vulgaris).

Whilst all
HPV lesions are infective, the SP appears to have an extremely low virulence and infectivity rate; it does
not seem to be contagious.

What are the signs and symptoms?

Typical presentation of the SP is of painless, solitary or multiple nodules measuring between 0.5cm to 3cm.

It is usually white but sometimes pink and has long or short surface projections with rounded or pointed ends.  It
often is on a stalk and only one lesion is usually found.  Once present, it remains indefinitely.
Photos of Squamous Papillomata
How is it treated?

The SP is treated effectively by simple surgical excision or scraping (curettage) of the base of the SP and a small
area of the surrounding normal tissue.

Alternative treatments include
cryotherapy, topical application of keratinolytic agents (usually containing salicylic
and lactic acid) or podophyllin or intra-lesional infiltration of α-interferon or imiquimod.

Recurrence is seen in a small proportion of treated cases.

Useful Websites:

Bond's Book of Oral Diseases (4th Edition) / The Maxillofacial Center for Diagnostics & Research

Brown Medical School, Digital Pathology

Marquette University School of Dentistry - Oral & Maxillofacial Pathology

Useful Articles:

ENT J 2000.  Oral Squamous Papilloma.  A View under Clinical, Fluorescence & Histopathological Aspects

J Egypt won Dermatol Soc 2008.  Human Papilloma Virus & Squamous Cell Carcinoma of the Oral Cavity

J Oral Sci 2009.  Oral Squamous Papilloma - Clinical, Histologic & Immunohistochemical Analyses

Int J Oral Sci 2010.  Squamous Papilloma - Case Report & Review of Literature

NEJM 2011.  Images in Clinical Medicine.  Human Papillomavirus Lesions of the Oral Cavity

Case Reports in Otolaryngology 2012.  Case Report.  Symptomatic Squamous Papilloma of the Uvula.  Report of a
Case & Review of the Literature

BMJ Case Reports 2013. Images in...Oral Squamous Papilloma.  Report of a Clinical Entity

J Stomat Occ Med 2013.  Squamous Papilloma.  Report of 2 Cases

Int J Dent Sci & Res 2014.  Oral Squamous Papilloma of the Palate - A Case Report

Ind J Dent 2014.  Case Report.  Squamous Papilloma of the Hard Palate

Einstein 2019.  Oral Squamous Papilloma.  A View under Clinical, Fluorescence & Histopathological Aspects
Last Updated 30th December 2019