Peripheral Ossifying Fibroma

(Peripheral Fibroma with Calcification,
Peripheral Ossifying Fibroma, Calcifying Fibroblastic Granuloma,
Peripheral Cementifying Fibroma, Peripheral Fibroma with
Cementogenesis & Peripheral Cemento-Ossifying Fibroma)
What are Peripheral Ossifying Fibromata?

The Peripheral Ossifying Fibroma (POF) is a relatively common reactive growth on the gingiva (gum), with a
histo-morphological pattern.

What are the Signs & Symptoms of a Peripheral Ossifying Fibroma?

POF’s occurs exclusively on the gingiva (often arising from the interdental papilla) and it is more common in children
and young adults, with a female predilection.  It is a fairly common lesion, comprising nearly 3% of oral lesions
biopsied in 1 study, approximately 1 – 2% in other studies.  

It presents as a well-defined, firm mass,
sessile (flattish) or pedunculated (stalked), usually covered by smooth
epithelium.  The surface is frequently ulcerated due to mechanical trauma.  Size varies from 5 – 20 mm in
diameter.  Approximately 60% of POFs occur in the
maxilla (upper jaw) and they occur more often in the anterior
(the front of the mouth) than the
posterior (at the back of the mouth) area with 55 – 60% presenting in the incisor-
(premolar) region.
Cases of tooth migration and bone destruction have been reported, but these are not common.
There is a female preponderance (suggestive of a hormonal component).  By most reports, the majority of the
lesions occur in the second decade (peaks in teenage years), with a declining incidence in later years.

There are 2 reported cases of POF present at birth, presenting clinically as
congenital epuli.  POF’s appears to be
more common among white people than black and slightly less common among those of Hispanic origin.

The lesion may be present for a number of months to years before excision, depending on the degree of ulceration,
discomfort and interference with function.

What are the causes of Peripheral Ossifying Fibromata?

POFs are believed to arise from gingival fibres of the periodontal ligament as hyperplastic growth of tissue that is
unique to the
gingival mucosa.

Some researchers believe POF’s to be related to
pyogenic fibromata and, in some instances, are the result of a
pyogenic granuloma which has undergone fibrosis and calcification.

How are they treated?

Treatment consists of conservative surgical excision and scaling of adjacent teeth.

Do they come back?

The rate of recurrence has been reported at 1.9%, 8.9%, 14%, 16% and 20%.  Therefore, regular follow-up is

Useful Websites:

Bond Book



DermNet NZ

Useful Articles:

Pediatric Dentistry 1998.  Peripheral Ossifying Fibroma associated with a Neonatal Tooth - Case Report

Pediatr Dent 2001.  Peripheral Ossifying Fibroma — A Clinical Evaluation of 134 Pediatric Cases

JCDA 2008.  Peripheral Ossifying Fibroma - A Case Report

People’s Journal of Scientific Research 2010.  Recurrence of Peripheral Ossifying Fibroma - A Case Report

Case Reports in Dentistry 2011.  Case Report.  Peripheral Ossifying Fibroma in the Oral Cavity - MRI Findings

Int J Case Reports & Images 2011.  Peripheral Ossifying Fibroma of Gingiva.  A Case Report

Int. J. Odontostomat 2011.  Peripheral Ossifying Fibroma – A Clinical Report

J Oral Maxillofac Res 2010.  Juvenile Ossifying Fibroma of the Mandible.  A Case Report
Photos of Peripheral Ossifying Fibromata
Last Updated 1st August 2012