Odontogenic Keratocyst (OKC)
Exodontia.Info
What is an Odontogenic Keratocyst (OKC)?

The
odontogenic keratocyst (OKC) is the most important of
the tooth-derived cysts.

This cyst may have any clinical appearance; it is a great
mimic and the diagnosis is made after microscopic analysis.

This is the third most common tooth-derived cyst.

These cysts also are found as part of the
Basal Cell Nevus
Syndrome
, also known as Gorlin syndrome.

What are the causes of Odontogenic Keratocysts?

Their cause is controversial.

One theory is that the
cyst develops instead of a tooth.  
Presumably, the cells that would form the tooth undergo
cystic degeneration without ever completing tooth formation
and develop into the
OKC.
Radiographs of Odontogenic Keratocysts present in the
lower jaw
The OKC has a number of 'compartments' and has
connecting smaller cysts that extend into the surrounding
bone.  Because of this, there is frequent tendency for the
condition to recur, particularly if the original surgical
treatment did not result in complete removal of the cyst.

Removal of the
cyst with removal of surrounding bone and /
or
cryosurgery (intense cold is applied to the cyst and bone)
are the most common forms of treatment.

Long-term follow-up with monitoring by X-ray is important,
as if these
cysts are left untreated, they can become quite
large and locally destructive.

J American Dent Association 2003.  Maxillary Odontogenic
Keratocyst.  A common and serious clinical mis-diagnosis.

J Oral Maxillofac Surg 2005.  Treatment of Keratocysts.
The Case for Decompression and Marsupialization

JOMS 2005. The Treatment of Odontogenic Keratocysts
by Excision of the Overlying, Attached Mucosa, Enucleation
& Treatment of the Bony Defect With Carnoy Solution

JOMS 2006.  A Retrospective Review of Treatment of the
Odontogenic Keratocyst

JOMS 2006.  Conservative Treatment Protocol of
Odontogenic Keratocyst - A Preliminary Study

JOMS 2006. Conservative Management of a Large
Odontogenic Keratocyst - Report of a Case & Review of
the Literature

Head & Neck Pathol 2010.  Keratocystic Odontogenic
Tumor

JOMS 2010.  Keratocystic Odontogenic Tumor vs
Odontogenic Keratocyst – The Issue Of Adequate
Nomenclature

BJOMS 2011. Technical Note.  Use of Methylene Blue for
Precise Peripheral Ostectomy of Keratocystic Odontogenic
Tumour

Oral Surgery 2012.  Treatment of a Patient with Large
Keratocystic Odontogenic Tumour in the Mandible. Case
Report with Literature Review


Cysts & Cystic Lesions of the Mandible

Chapter 12.  Cysts of the Jaws

Power Point Presentation about the Origin of Odontogenic
Cysts & Tumours
Odontogenic Keratocysts - Key Features

  • Usually, multi-locular (many compartments)
  • Form intra-osseously (within bone), most frequently in
    the posterior (back) alveolar ridge or angle of the
    mandible (lower jaw)
  • May grow around a tooth
  • Spreads extensively along marrow spaces before
    expanding into the jaw
  • Frequently recurs after enucleation
  • Does not respond to marsupialisation
  • Definitive diagnosis only by histo-pathology, although
    clinical & radiographic features may allow fairly
    accurate pre-operative diagnosis
  • May be easily confused with ameloblastoma or, less
    likely, with dentigerous cysts
  • May be part of the jaw cyst / basal cell naevus
    syndrome
Last Updated 10th February 2012