Numb Chin Syndrome /
Mental Nerve Neuropathy
Useful Articles:

New Eng J Med 1994. The Numb Chin Syndrome

Respiratory Medicine 1997.  Case Reports.  Metastatic Large Cell Lung Cancer
presenting with Numb Chin Syndrome

Tr J Med Sci 1999.  Tooth Pain and Numb Chin as the Initial Presentation of
Systemic Malignancy

Hospital Physician 2000.  Numb Chin Syndrome - A Subtle Clue to Possible
Serious Illness

Arch Iranian Med 2005.  “Numb Chin” as the First & Sole Presenting Sign of
Multiple Sclerosis

World J Surg Oncol 2006.  Numb Chin Syndrome – A Reflection of Systemic

British Dental Journal 2010.  Numb Chin Syndrome - A Case Series & Discussion

British Dental Journal 2010.  Numb Chin Syndrome - An Ominous Clinical Sign

Dent Update 2010.  Numb Chin Syndrome - A Metastatic Deposit in the Mandible

Ind J Dent Res 2010.  Numb Chin Syndrome.  A Case Report & Review of the

Annali di Stomatologia 2013.  Numb Chin Syndrome

Int J Surg Case Reports 2013.  Unusual presentation of Numb Chin Syndrome’ as
the Manifestation of Metastatic Adenocarcinoma of the Lung

Dental Update 2017.  Case Report – Metastatic  Infratemporal  Soft Tissue
Myeloma Presenting as a Numb Lower Lip
What is Numb Chin Syndrome (NCS) / Mental Nerve

Numb Chin Syndrome (NCS), also known as mental nerve
, is characterised by facial and oral numbness,
rarely pain, restricted to the distribution of the
mental nerve
of the
inferior alveolar nerve.
Useful Websites:
Distribution of Mental Nerve & Numbness associated with
Mental Nerve Neuropathy
Although NCS is most commonly associated with non-malignant disease states, it
may be the presenting symptom of a systemic malignancy and its prompt
recognition is essential for proper management.
NCS is most commonly seen as a
manifestation of local dental disease
but it becomes clinically more
significant when it is associated with
neoplastic processes, particularly with
breast cancer and malignant
lymphomata, as any malignant
metastasis to the head & neck region
shows poor prognosis.

Dental causes, especially
ones (such as oral
surgery), are by far the most
common; if not related to those, this
complaint is considered a “
red flag
symptom of a distant malignant

When confronted with a possible
diagnosis of
NCS, clinical evaluation
should include evaluation for occult
malignancy or relapse of any known
previous cancer.

Careful medical history is required to
alert the clinician to appropriate
diagnostic procedures and ensure
correct management.
The association of NCS with
metastatic malignant disease has
been called
Roger's sign.

Dentists need to be aware of the
relationship between malignancies
and paræsthesia or complete loss
of sensation in a jaw segment.

In particular, dentists should be
aware of
NCS and its clinical
manifestations, as well as the
limitations of using panoramic
radiographs to detect the
causative malignancy.
Last Updated 13th June 2017